A new pancreatic lipase inhibitor from Broussonetia kanzinoki

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2760-3. doi: 10.1016/j.bmcl.2012.02.088. Epub 2012 Mar 7.

Abstract

A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4'-dihydroxyflavan (4), 3',7-dihydroxy-4'-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4'-methoxyflavone (6), 3,7,3'-trihydroxy-4'-methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC(50) of 28.4 μM. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipocytes / drug effects
  • Animals
  • Binding, Competitive / drug effects
  • Broussonetia / chemistry*
  • Cell Differentiation / drug effects
  • Enzyme Activation / drug effects
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Inhibitory Concentration 50
  • Lipase / antagonists & inhibitors*
  • Mice
  • Molecular Structure
  • Pancreas / enzymology*
  • Phenols / chemistry*
  • Phenols / pharmacology*

Substances

  • Enzyme Inhibitors
  • Phenols
  • broussonone A
  • Lipase